Doxycycline 100mg

Doxycycline 100mg

Doxycycline 100mg

Active ingredient:  Doxycycline

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Doxycycline 100mg is used to treat many different bacterial infections, such as acne, urinary tract infections, intestinal infections, respiratory infections, eye infections, gonorrhea, chlamydia, syphilis, periodontitis (gum disease), and others.




General information

What is Doxycycline 100mg ?

Doxycycline 100mg is a tetracycline antibiotic that fights bacteria in the body.

Doxycycline 100mg is used to treat many different bacterial infections, such as acne, urinary tract infections, intestinal infections, respiratory infections, eye infections, gonorrhea, chlamydia, syphilis, periodontitis (gum disease), and others.

Doxycycline 100mg is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea. It will not treat facial redness caused by rosacea.

Some forms of Doxycycline are used to prevent malaria, to treat anthrax, or to treat infections caused by mites, ticks, or lice.

Doxycycline is available under the following different brand names: Vibramycin, Monodox, Acticlate, Atridox, Avidoxy, Doxy, Doxycin, Doryx, Oracea, Periostat, Adoxa, Ocudox, and Doryx MPC.

Directions

The capsules should be swallowed with plenty of fluid in either the resting or standing position and well before going to bed for the night to reduce the likelihood of oesophageal irritation and ulceration.

If gastric irritation occurs, it is recommended that Doxycycline Capsules be given with food or milk. Studies indicate that the absorption of doxycycline is not notably influenced by simultaneous ingestion of food or milk.

Posology

Adults and children aged 12 years to less than 18 years

The usual dosage of Doxycycline for the treatment of acute infections in adults and children aged 12 years to less than 18 years is 200mg on the first day (as a single dose or in divided doses with a twelve hour interval) followed by a maintenance dose of 100mg/day. In the management of more severe infections (particularly chronic infections of the urinary tract), 200mg daily should be given throughout the treatment period.

Exceeding the recommended dosage may result in an increased incidence of side effects. Therapy should be continued for at least 24 to 48 hours after the symptoms and fever have subsided.

When used in streptococcal infections, therapy should be continued for 10 days to prevent the development of rheumatic fever or glomerulonephritis.

Dosage recommendations in specific infections:

Acne vulgaris

  • 50mg daily with food or fluid for 6 to 12 weeks.

Sexually transmitted diseases

  • Take Doxycycline 100mg twice daily for 7 days is recommended in the following infections: uncomplicated gonococcal infections (except anorectal infections in men); uncomplicated urethral, endocervical or rectal infection caused by Chlamydia trachomatis; non-gonococcal urethritis caused by Ureaplasma urealyticum.
  • Acute epididymo-orchitis caused by Chlamydia trachomatis or Neisseria gonorrhoea 100mg twice daily for 10 days.
  • Primary and secondary syphilis:300mg a day in divided doses for at least 10 days.
  • Louse and tick-borne relapsing fevers
  • A single dose of 100mg or 200mg according to severity.

Treatment of chloroquine-resistant falciparum malaria

  • 200mg daily for at least 7 days. Due to the potential severity of the infection, a rapid- acting schizonticide such as quinine should always be given in conjunction with Doxycycline; quinine dosage recommendations vary in different areas.

Prophylaxis of malaria

100mg daily in adults and children over the age of 12 years. Prophylaxis can begin 1-2 days before travel to malarial areas. It should be continued daily during travel in the malarial areas and for 4 weeks after the traveller leaves the malarial area. For current advice on geographical resistance patterns and appropriate chemoprophylaxis, current guidelines or the Malaria Reference Laboratory should be consulted, details of which can be found in the British National Formulary (BNF).

For the prevention of scrub typhus

200mg as a single dose.

For the prevention of travellers' diarrhoea in adults

200mg on the first day of travel (administered as a single dose or as 100mg every 12 hours) followed by 100mg daily throughout the stay in the area. Data on the use of the drug prophylactically are not available beyond 21 days.

For the prevention of leptospirosis

200mg once each week throughout the stay in the area and 200mg at the completion of the trip. Data on the use of the drug prophylactically are not available beyond 21 days.

The use of doxycycline for the treatment of acute infections in children aged 8 years to less than 12 years should be carefully justified in situations where other drugs are not available, are not likely to be effective or are contraindicated.

In such circumstance, the doses for the treatment of acute infections are:

For children 45 kg or less- Initial dose: 4.4 mg/kg (in single or 2 divided doses) with maintenance dose: 2.2 mg/kg (in single or 2 divided doses). In the management of more severe infections, up to 4.4 mg/kg should be given throughout treatment.

For children, over 45 kg - Dose administered for adults should be used.

Children aged from birth to less than 8 years.

Doxycycline should not be used in children aged younger than 8 years due to the risk of teeth discolouration.

Elderly patients

Doxycycline may be prescribed in the usual dose with no special precautions. No dosage adjustment is necessary in the presence of renal impairment.

Renal impairment: Studies to date have indicated that administration of doxycycline at the usual recommended doses does not lead to excessive accumulation of the antibiotic in patients with renal impairment.

The anti-anabolic action of the tetracyclines may cause an increase in blood urea. Studies to date indicate that this does not occur with the use of doxycycline in patients with impaired renal function.

Haemodialysis does not alter the serum half-life of Doxycycline.

Contraindications

Hypersensitivity to the active substance, any of the tetracyclines or to any of the excipients listed in section 6.1

Pregnancy: Doxycycline is contraindicated in pregnancy (see section 4.6). It appears that the risks associated with the use of tetracyclines during pregnancy are predominantly due to effects on teeth and skeletal development

Nursing mothers: Tetracyclines are excreted into milk and are therefore contraindicated in nursing mothers.

 Sucrose intolerance: Patients with rare hereditary problems of fructose intolerance, glucose galactose malabsorption or sucrose-isomaltase insufficiency should not take doxycycline.   

Doxycycline side effects

Get emergency medical help if you have any signs of an allergic reaction to doxycycline: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using doxycycline.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;
  • throat irritation, trouble swallowing;
  • chest pain, irregular heart rhythm, feeling short of breath;
  • little or no urination;
  • low white blood cell counts - fever, chills, swollen glands, body aches, weakness, pale skin, easy bruising or bleeding;
  • severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;
  • loss of appetite, upper stomach pain (that may spread to your back), tiredness, nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes).

Common doxycycline side effects may include:

  • nausea, vomiting, upset stomach, loss of appetite;
  • mild diarrhea;
  • skin rash or itching;
  • darkened skin color; or
  • vaginal itching or discharge.

Drug Interactions

What Other Drugs Interact with Doxycycline?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Severe Interactions of doxycycline include:

  • acitretin
  • allogeneic cultured keratinocytes/fibroblasts in bovine collagen
  • flibanserin
  • lomitapide
  • tretinoin

Doxycycline has serious interactions with at least 67 different drugs.

Doxycycline moderate interactions with at leas 51 different drugs.

Doxycycline 100mg moderate interactions with at leas 32 different drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Storage

Store Doxycycline 100mg at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store the drugs in the bathroom. Keep all drugs away from reach of children and pets.

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